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Experience inheritance from famous specialists based on real-world clinical research paradigm of traditional

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《医学前沿（英文）》 2014年 第8卷 第3期   页码 300-309 doi: 10.1007/s11684-014-0357-8

摘要：

The current modes of experience inheritance from famous specialists in traditional Chinese medicine (TCM) include master and disciple, literature review, clinical-epidemiology-based clinical research observation, and analysis and data mining via computer and database technologies. Each mode has its advantages and disadvantages. However, a scientific and instructive experience inheritance mode has not been developed. The advent of the big data era as well as the formation and practice accumulation of the TCM clinical research paradigm in the real world have provided new perspectives, techniques, and methods for inheriting experience from famous TCM specialists. Through continuous exploration and practice, the research group proposes the innovation research mode based on the real-world TCM clinical research paradigm, which involves the inheritance and innovation of the existing modes. This mode is formulated in line with its own development regularity of TCM and is expected to become the main mode of experience inheritance in the clinical field.

关键词： traditional Chinese medicine (TCM)     real world     clinical research paradigm     famous specialist     experience inheritance    

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exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic inheritance

《医学前沿（英文）》 2022年 第16卷 第2期   页码 176-184 doi: 10.1007/s11684-021-0885-y

摘要： Studies of human and mammalian have revealed that environmental exposure can affect paternal health conditions as well as those of the offspring. However, studies that explore the mechanisms that meditate this transmission are rare. Recently, small noncoding RNAs (sncRNAs) in sperm have seemed crucial to this transmission due to their alteration in sperm in response to environmental exposure, and the methodology of microinjection of isolated total RNA or sncRNAs or synthetically identified sncRNAs gradually lifted the veil of sncRNA regulation during intergenerational inheritance along the male line. Hence, by reviewing relevant literature, this study intends to answer the following research concepts: (1) paternal environmental factors that can be passed on to offspring and are attributed to spermatozoal sncRNAs, (2) potential role of paternal spermatozoal sncRNAs during the intergenerational inheritance process, and (3) the potential mechanism by which spermatozoal sncRNAs meditate intergenerational inheritance. In summary, increased attention highlights the hidden wonder of spermatozoal sncRNAs during intergenerational inheritance. Therefore, in the future, more studies should focus on the origin of RNA alteration, the target of RNA regulation, and how sncRNA regulation during embryonic development can be sustained even in adult offspring.

关键词： small noncoding RNAs     epigenetic inheritance     paternal intergenerational inherence     extracellular vesicles    

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Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

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《医学前沿（英文）》 2014年 第8卷 第4期   页码 419-426 doi: 10.1007/s11684-014-0383-6

摘要：

Aneurysmal dilatation of the aortic sinuses of Valsalva has been most extensively documented in the setting of aortopathies, particularly Marfan syndrome. On the other hand, there is limited data in the literature about congenital sinus of Valsalva aneurysms outside this context. For the purpose of this review, we carried out a literature search on aneurysmal dilatation of the sinuses of Valsalva in Marfan syndrome, and compared this with congenital sinus of Valsalva aneurysms, also including data from a case series from our institution. In conclusion, there are differences in management of aortic dilatation in Marfan syndrome and congenital sinus of Valsalva aneurysms. Though less well-recognised, congenital aneurysms are often associated with significant morbidity and mortality and timely intervention is necessary.

关键词： sinus of Valsalva aneurysms     Marfan syndrome     aortic dissection    

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Taizhou’s COVID-19 prevention and control experience with telemedicine features

Cenyi Shao, Shijian Li, Feng Zhu, Dahai Zhao, Hui Shao, Haixiao Chen, Zhiruo Zhang

《医学前沿（英文）》 2020年 第14卷 第4期   页码 506-510 doi: 10.1007/s11684-020-0811-8

摘要： The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly around the world. As of May 30, 2020, a total of 84 568 confirmed COVID-19 cases have been recorded in China, with a mortality rate of approximately 5.5%. Taizhou is a prefecture-level city in Zhejiang Province. A total of 146 cases were diagnosed in this epidemic, with a fatality rate of 0%. This condition is due to the establishment of an “Internet+” diagnosis and treatment model based on online medical application (APP), telemedicine, WeChat service, and consultation hotline in Taizhou. Taizhou led in opening the “COVID-19 Prevention and Treatment Special Line” in China, which is conducive to pre-hospital screening, suppressing social panic, and clinical support. Hospitals also carried out related online lectures and popularization of science. We summarize Taizhou’s COVID-19 prevention and control experience with telemedicine features, with a view to providing reference for the control of the epidemic at home and abroad.

关键词： COVID-19     telemedicine     prevention experience    

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Thinking and practice of accelerating transformation of traditional Chinese medicine from experience

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

《医学前沿（英文）》 2011年 第5卷 第2期   页码 163-170 doi: 10.1007/s11684-011-0143-9

摘要： The gradual development of Chinese medicine is based on constant accumulation and summary of experience in clinical practice, but without the benefit of undergoing the experimental medicine stage. Although Chinese medicine has formed a systematic and unique theory system through thousands of years, with the development of evidence-based medicine, the bondage of the research methods of experience medicine to Chinese medicine is appearing. The rapid transition and transformation from experience medicine to evidence-based medicine have become important content in the development of Chinese medicine. According to the features of Chinese medicine, we propose the research idea of “taking two ways simultaneously,” which is the study both in the ideal condition and in the real world. Analyzing and constructing the theoretical basis and methodology of clinical research in the real world, and building the stage for research technique is key to the effective clinical research of Chinese medicine. Only by gradually maturing and completing the clinical research methods of the real world could we realize “taking two ways simultaneously” and complementing each other, continuously produce scientific and reliable evidence of Chinese medicine, as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine.

关键词： Chinese medicine     experience medicine     evidence-based medicine     real world    

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Inheritance and Innovation of Engineering Management Informatization

Kai Sun,Ren-huai Liu

《工程管理前沿（英文）》 2014年 第1卷 第1期   页码 76-82 doi: 10.15302/J-FEM-2014014

摘要： In the life-cycle of large projects, the operational phase lasts the longest, costs the most and substantially benefits the project. During the whole phase, energy, material and human resources may cost a lot. Effective control of such costs is one of the main targets of engineering management informatization. How to lower the organization collaboration cost in project management and how to support effective collaboration among different areas, organizations and departments in the ways of technology and management are major goals in engineering management informatization. In the phase of project operation, project owners, partners and customers are the stakeholders of engineering management informatization. Through the case of airport management informatization, inherited and innovation of engineering management informatization will be discussed. It is illustrated that airport informatization is the innovation of business model and technology applications through the analysis and study on cases of airport informatization.

关键词： engineering management     informatization     inter-organizational relationship     management creation     resource sharing    

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Knowledge-based competitive strategy using direct customer experience for automobile product development

Peter HODGES, Shuh Yuan LIOU,

《机械工程前沿（英文）》 2010年 第5卷 第1期   页码 33-46 doi: 10.1007/s11465-009-0080-3

摘要： The automobile product development (PD) design space continually increases in size and complexity. In this dynamic environment, firms must identify competitive strategies that maintain or increase financial return. Firms can compete on several factors including price/cost, time-to-market, or differentiation (e.g., function or quality). Here, we envision that differentiation through expertise in integration can be a successful strategy in the automotive industry. Expertise in integration requires attention to knowledge management, which is crucial for competitive advantage []. A key component of the PD process is the acquisition of data about customers’ responses to vehicle performance and the rapid use of that information in the development of new products. The paper proposes a system for collecting near real-time data about responses to vehicle performance and its integration with recent developments in design and analysis. The proposed system would collect customer psychophysical response data, correlate it with vehicle parameter response data, and apply this information with feasible design automation to provide reduced cycle time, improved quality, and greater customer satisfaction. The paper discusses some relevant technological and legal constraints and concludes that such a system is feasible, can provide a near-term competitive advantage, and in the long-term, in some form, will be necessary for success.

关键词： product development     strategy     knowledge management    

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Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive

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《医学前沿（英文）》 2013年 第7卷 第3期   页码 395-395 doi: 10.1007/s11684-013-0289-8

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A stepwise process for carbon dioxide sequestration using magnesium silicates

Johan FAGERLUND, Experience NDUAGU, Ron ZEVENHOVEN, Inês ROMÃO,

《化学科学与工程前沿（英文）》 2010年 第4卷 第2期   页码 133-141 doi: 10.1007/s11705-009-0259-5

摘要： This work involves the production of magnesium in the form of Mg(OH) from serpentinite rock (nickel mine tailing) material followed by conversion into MgCO using a pressurised fluidised bed (PFB) reactor operating at 400°C–600°C and pressures up to 2.85MPa. Our approach is rooted in the thermodynamic fact that the reaction between Mg(OH) and gaseous CO forming MgCO and water releases significant amounts of heat. The main problem is, however, the chemical kinetics; the reaction is slow and has to be accelerated in order to be used in an economically viable process for large-scale (~1Mt/a) CO sequestration. We have constructed a lab-scale PFB reactor test-setup for optimising the carbonation reaction. At high enough temperatures and conversion levels the reaction should provide the heat for the proceeding Mg(OH) production step, making the overall process energy neutral. So far we have been able to achieve a conversion degree of 26% at 500°C and 2.85MPa after 30min (particle size 125–212μm). In this paper the test facility and our latest results and progress on CO mineral carbonation are summarised. Also, the possible integration of the iron as a feedstock for iron and steel production will be briefly addressed. An interesting side-effect of this carbon dioxide capture and storage (CCS) route is that significant amounts of iron are obtained from the serpentinite rock material. This is released during the Mg(OH) production and can be of great interest to the iron- and steel producing sector, which at the same time is Finland’s largest CO producer.

关键词： carbonation reaction     reactor     producer     large-scale     process    

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Practice and Experience of Canton Tower Project Management

Rong-hua Yi

《工程管理前沿（英文）》 2016年 第3卷 第1期   页码 74-79 doi: 10.15302/J-FEM-2016013

摘要： This paper presents a brief introduction about the preliminary consulting and tender agent of Canton Tower, the basic situation of the whole-process supervision on the construction site, and a general summary of the Canton Tower project management. What’s more, the author suggests that some guidelines be formed for supervision enterprises involved in large-scale project management.

关键词： Canton Tower     consultation     tender agent     whole-process     supervision    

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无/低代码软件开发的兴起——无需经验？

Marcus Woo

《工程（英文）》 2020年 第6卷 第9期   页码 960-961 doi: 10.1016/j.eng.2020.07.007

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Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoietic

Meng Lv, Yingjun Chang, Xiaojun Huang

《医学前沿（英文）》 2019年 第13卷 第1期   页码 45-56 doi: 10.1007/s11684-017-0595-7

摘要： Human leukocyte antigen (HLA)-matched donors for hematopoietic stem cell transplantation (HSCT) have long been scarce in China. Haploidentical (haplo) donors are available for the vast majority of patients, but toxicity has limited this approach. Three new approaches for haplo-HSCT originated from Italy, China, and USA in 1990 and have been developed to world-renowned system up to now. The Chinese approach have been greatly improved by implementing new individualized conditioning regimens, donor selection based on non-HLA systems, risk-directed strategies for graft-versus-host disease and relapse, and infection management. Haplo-HSCT has exhibited similar efficacy to HLA-matched HSCT and has gradually become the predominant donor source and the first alternative donor choice for allo-HSCT in China. Registry-based analyses and multicenter studies adhering to international standards facilitated the transformation of the unique Chinese experience into an inspiration for the refinement of global practice. This review will focus on how the new era in which “everyone has a donor” will become a reality in China.

关键词： haploidentical hematopoietic stem cell transplantation     conditioning     graft-versus-host disease     relapse     infection     donor selection    

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Diagnosis and treatment for advanced hilar cholangiocarcinoma: experience of 24 cases

ZHANG Zongming, ZHU Jianping, SU Yanming, GUO Jinxing, JIANG Nan, ZHANG Zichao, XING Hailin, LIU Kai, YUAN Haiming

《医学前沿（英文）》 2008年 第2卷 第2期   页码 134-138 doi: 10.1007/s11684-008-0025-y

摘要： The aim of this paper is to evaluate the efficacy of the surgical treatment for advanced hilar cholangiocarcinoma (CCA) in order to improve the resection rate and curative effect. A retrospective analysis was performed on the data of 24 patients who had undergone surgical treatment for advanced hilar CCA. According to the Bismuth classification, there were four cases of type IIIa, six cases of type IIIb, and 14 cases of type IV. Based on the treatment approaches, these patients were divided into three groups: $` Radical resection group: There were five cases (one type IIIa, three type IIIb, and one type IV). The tumor visible to the naked eyes was resected thoroughly and the cut margin was free of tumor by microscopic examination. Then, Roux-en-Y hepatico-jejunal anastomosis was performed to restore the bile flow. $a Palliative resection group: There were 11 cases. The bile flow was restored by Roux-en-Y hepatico-jejunal anastomosis directly in five cases (two type IIIa, three type IIIb) and by internal drainage through a hepatico-jejunal bridge in the other six cases (one type IIIa, five type IV). $b Simple internal biliary drainage group: There were eight cases of type IV, including three cases with the internal drainage through hepatico-jejunal bridge by laparotomy, three cases with endoscopic retrograde biliary drainage (ERBD), two cases with percutaneous transhepatic biliary drainage (PTBD). The rate of radical resection was 20.8% and the overall resection rate was 66.7%. All of the 24 patients were followed-up. The cumulative surviving rates were significantly different among these three groups (Log-rank = 17.56, = 0.0002). For advanced hilar CCA, the best choice of treatment is radical resection. If radical resection is impractical, palliative resection combined with partial hepatectomy can significantly prolong the survival time. Internal drainage through a hepatico-jejunal bridge can enhance the surgical resection rate and decrease the occurrence rate of postoperative biliary leakage.
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Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated

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《医学前沿（英文）》 2015年 第9卷 第1期   页码 63-71 doi: 10.1007/s11684-014-0342-2

摘要：

Cryoablation is a less prevalent percutaneous ablative therapy for hepatocellular carcinoma (HCC), and current evidence about its usefulness is limited. We report our experience in treating 1595 HCC cases with percutaneous cryoablation to give a comprehensive profile about the effectiveness, safety and long-term outcome of this therapy. From January 2003 to December 2013, 1595 patients with 2313 HCC nodules were ablated with 2945 cryoablation sessions in our center. Complete ablation was achieved in 1294 patients for 1893 nodules with a mean diameter of 3.4±2.2 cm. The complete ablation rate was 81.2%, 99.4%, 94.4%, and 45.6% in all tumors, tumors<3 cm, tumors<5 cm, and tumors>5 cm, respectively. Major complications were observed after 80 (3.4%) of the 2945 cryoablations and minor complications were observed after 330 cryoablations with no treatment-related deaths. After a median follow-up of 33.4 months, 937 patients developed different types of recurrence. The 5- and 10-year overall survival was 25.7% and 9.2%, respectively. Cryoablation showed reliable safety and efficacy and should be considered as a promising technique, particularly when a large zone of ablation is required.

关键词： hepatocellular carcinoma     percutaneous cryoablation     efficacy     safety    

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Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the

《医学前沿（英文）》 2023年 第17卷 第1期   页码 165-171 doi: 10.1007/s11684-022-0961-y

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标题 作者 时间 类型 操作

Experience inheritance from famous specialists based on real-world clinical research paradigm of traditional

null

期刊论文

exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic inheritance

期刊论文

Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

null

期刊论文

Taizhou’s COVID-19 prevention and control experience with telemedicine features

Cenyi Shao, Shijian Li, Feng Zhu, Dahai Zhao, Hui Shao, Haixiao Chen, Zhiruo Zhang

期刊论文

Thinking and practice of accelerating transformation of traditional Chinese medicine from experience

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

期刊论文

Inheritance and Innovation of Engineering Management Informatization

Kai Sun,Ren-huai Liu

期刊论文

Knowledge-based competitive strategy using direct customer experience for automobile product development

Peter HODGES, Shuh Yuan LIOU,

期刊论文

Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive

null

期刊论文

A stepwise process for carbon dioxide sequestration using magnesium silicates

Johan FAGERLUND, Experience NDUAGU, Ron ZEVENHOVEN, Inês ROMÃO,

期刊论文

Practice and Experience of Canton Tower Project Management

Rong-hua Yi

期刊论文

无/低代码软件开发的兴起——无需经验？

Marcus Woo

期刊论文

Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoietic

Meng Lv, Yingjun Chang, Xiaojun Huang

期刊论文

Diagnosis and treatment for advanced hilar cholangiocarcinoma: experience of 24 cases

ZHANG Zongming, ZHU Jianping, SU Yanming, GUO Jinxing, JIANG Nan, ZHANG Zichao, XING Hailin, LIU Kai, YUAN Haiming

期刊论文

Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated

null

期刊论文

Management and operation of extra-large Fangcang hospitals: experience and lessons from containing the

期刊论文